Schizophrenia has attracted more than its fair share of evolutionary-based theories. The theories involving balancing selection are based on the assumption that the incidence of schizophrenia is invariant across time and place. Modern epidemiology allows us to reject this dogmatic belief. Once variations in the genetic and epidemiological landscape of schizophrenia are acknowledged, more productive research models can be generated. (Published Online November 9 2006).

Crespi & Badcock (C&B) present an appealing and parsimonious synthesis arguing that schizophrenia and autism are differentially regulated by maternal versus paternal genomic imprinting, respectively. We argue that animal models related to schizophrenia and autism provide a useful platform to explore the mechanisms outlined by C&B. We also note that schizophrenia and autism share certain risk factors such as advanced paternal age. Apart from genomic imprinting, copy number variants related to advanced paternal age may also contribute to the differential trajectory (...) of brain development associated with autism and schizophrenia. (shrink)

The Mandaean Book of John: Critical Edition, Translation and Commentary. Edited by Charles G. Häberl and James F. McGrath. Berlin: Walter De Gruyter, 2020. Pp. vii + 467. $218.99.

In the last two decades, interest in narrative conceptions of identity has grown exponentially, though there is little agreement about what a "life-narrative" might be. In connecting Kierkegaard with virtue ethics, several scholars have recently argued that narrative models of selves and MacIntyre's concept of the unity of a life help make sense of Kierkegaard's existential stages and, in particular, explain the transition from "aesthetic" to "ethical" modes of life. But others have recently raised difficult questions both for these readings (...) of Kierkegaard and for narrative accounts of identity that draw on the work of MacIntyre in general. While some of these objections concern a strong kind of unity or "wholeheartedness" among an agent's long-term goals or cares, the fundamental objection raised by critics is that personal identity cannot _be_ a narrative, since stories are artifacts made by persons. In this book, Davenport defends the narrative approach to practical identity and autonomy in general, and to Kierkegaard's stages in particular. (shrink)

Cleary discusses the origin, development, and use of the many senses of priority as a central thesis in Aristotle’s metaphysics. Cleary contends that one of the most revealing problems for the ambiguity of Aristotle’s relationship to Platonism is that of the ontological status of mathematical objects. In support of his claim, Cleary analyzes a curious passage from Aristotle’s _Topics, _where he appears to accept a schema of priorities that makes mathematical entities more substantial than sensible things. How does Aristotle try (...) to reconcile the ordering of things dictated by sciences like mathematics and dialectic with the ordering of sense experience upon which his own physics and metaphysics are based? To find the answer, Cleary reviews three different outlines of the many senses of priority given by Aristotle himself and found in _Categories _12-13, _Metaphysics _Delta 11, and _Metaphysics _Theta 8. Cleary suggests there is an implicit hierarchy for Aristotle that leads him to posit the Prime Mover at its apex as complete actuality and, therefore, as the focus for the concept of priority. Having reviewed Aristotle’s treatment of the many uses of priority, Cleary demonstrates how the concept is used in some typical arguments by Aristotle for his mature metaphysical positions. (shrink)

The 1990s saw a revival of interest in Kierkegaard's thought, affecting the fields of theology, social theory, and literary and cultural criticism. The resulting discussions have done much to discredit the earlier misreadings of Kierkegaard's works.

The interpretation of transcendental arguments remains a contentious issue for contemporary epistemology. It is usually agreed that they originated in Kant's theoretical philosophy and were intended to have some kind of anti-sceptical efficacy. I argue that the sceptic with whom Kant was concerned has been consistently misidentified. The actual sceptic was Hume, questioning whether the faculty of reason can justify any of our judgements whatsoever. His challenge is a sceptical argument regarding rule-following which engenders a vicious regress. Once this sceptical (...) threat is properly identified, the prospects of transcendental arguments must be re-evaluated. (shrink)

This article argues for a social proviso concerning capital endowments that is analogous to Locke's original proviso on access to productive natural capital.

In a recent essay, George Annas, the legal columnist for The New England Journal of Medicine, observed that the resuscitation of extremely premature infants, even over parental objection, is not problematic because “once the child's medical status has been determined, the parents have the legal authority to make all subsequent decisions.” Annas himself is quick to concede that treatment in a high-technology neonatal intensive care unit frequently takes on a life of its own. He also acknowledges that although bioethicists and (...) courts agree that there is no ethical or legal difference between withholding or withdrawing a respirator from a patient, parents and physicians find the withdrawal much more emotionally troubling. (shrink)

I have argued that like Harry Frankfurt, Augustine implicitly distinguishes between first-order desires and higher-order volitions; yet unlike Frankfurt, Augustineheld that the liberty to form different possible volitional identifications is essential to responsibility for our character. Like Frankfurt, Augustine recognizes that we can sometimes be responsible for the desires on which we act without being able to do or desire otherwise; but for Augustine, this is true only because such responsibility for inevitable desires and actions traces (at least in part) (...) to responsibility for our volitional identifications, which in turn has leeway-libertarianconditions. However, David Hunt has interpreted Augustine’s account of divine foreknowledge as implying a type of source-incompatibilism that does not require alternative possible actions or intentions. Moreover, while Eleonore Stump’s account of Augustine on sanctification supports my interpretation, Augustine’s position on predestination in his latest writings may be incompatible with liberty of the higher-order will. I will argue against Hunt’s interpretation but admit that the leeway-libertarian has to reject the ‘no autonomy’ model in some of Augustine’s late writings. (shrink)

Cellular interactions in the mammalian ovarian follicle between its germ‐line and somatic cell components are crucial for its development and function. These interactions are mediated by both membrane gap junctions and paracrine factors. Somatic cell‐to‐oocyte communication is essential for oocyte growth and the regulation of meiotic maturation. In particular, granulosa cells provide nutrients and molecular signals that regulate oocyte development. Oocytes, on the other hand, promote the organization of the follicle, the proliferation of granulosa cells, and the differentiation and function (...) of cumulus cells, a subset of granulosa cells. Determining the nature of the oocyte‐to‐granulosa cell signals remains a key challenge for future work. (shrink)

This article investigates William James's reading of the concepts of selflessness and transcendence in relation to the Chan and Pure Land schools of Chinese Buddhism. The divide between Chan and Pure Land Buddhism may be mediated if we attend to aspects of the two traditions that James found particularly meaningful. James is drawn to selflessness as presented in the concept of emptiness in the Chan understanding of meditative experience. He is equally interested in Buddhist devotional practices of Pure Land that (...) claim to open individuals and their communities to the divine. James saw these two aspects as deeply compatible. (shrink)

This volume contains papers originally presented to the Boston Area Colloquium in Ancient Philosophy during 2005-6. Of the seven colloquia, two deal with topics in Neoplatonism, four are dedicated to Aristotle’s ethics and metaphysics, and one to Plato’s Republic.

How does a self-described “simple teacher of religion” at the College of the Holy Cross get involved in bioethics? Nothing in my training or experience had prepared me for involvement in medicine. Much like that of my moral theology professor and then mentor, Richard McCormick, my training was in moral theology and social ethics. I also had an abiding interest in the courts and constitutional law. That interest led to a doctoral dissertation at the University of Southern California's Program in (...) Social Ethics on “The Supreme Court's Understanding of Religion in Conscientious Objector Cases.” Interestingly, doctoral work in the late 1960s on the ethical dimension of war was the starting point for other ethicists such as Leroy Walters and James Childress who subsequently became early voices in bioethics. (shrink)

The Clinton administration's revised rules regulating but not prohibiting the common practice in managed care of linking physician compensation with cost cutting and control of services demonstrates the complexity of ethical issues in managed care. As originally proposed, the federal guidelines on payment for Medicare and Medicaid services would have precluded any interrelationship between payment to physicians and delivery of services. Such a restriction would have gutted the primary mechanism in managed care plans to curb the unacceptably high cost of (...) healthcare delivery: making physicians directly responsible for cost control by placing them at direct financial risk. At first blush such a linkage seems to involve an obvious and irreconcilable conflict of interest. How can a physician be responsible for the well-being of a patient while at the same time aware that a proportion of his or her income is linked to the provision of cost-conscious care? (shrink)

The issue of physician refusal of requested treatment has fueled a two-pronged debate in our society-one on the meaning of futility and the other on the limits of patient autonomy. The latter is a genuinely philosophic dispute; the former, it seems, is a modern relapse into nominalism.It is not the meaning of a word, but the moral basis for the actions of the par-ticipants that should be the focus of our attention, Yet the medical literature distracts us with articles titled (...) “Medical Futility: Its Meaning and Ethical Implica-tions” “The Problem with Futility” “Who Defines Futility?,” “The Illusion of Futility,” and even “Beyond Futility.”The history of the futility debate, which was launched by a 1983 study of Bedell and Delbanco that demonstrated the ineffectiveness of CPR for certain catego-ries of patients, has been documented elsewhere. Here we will inquire if the term, and its rapid intrusion into the medical lexicon, serves a useful purpose or if, as Truog suggested, we would all be better off if this new buzzword were jettisoned. (shrink)

The history of Western Thought since the seventeenth Century leaves little doubt as to the practical validity of the method of natural investigation discovered by Galileo, interpreted by Descartes, and variously generalized by Newton and Einstein. The repercussions of its success on every level of human activity, religious, political, commercial, and educational have awakened the most diverse ánd even contradictory speculations as to the nature of this science and the objectives of the scientist. Often enough one gets the impression that (...) these speculations are founded on an arbitrary and unjustifiable conception of the nature of modern science; a conception formulated in terms of what one thinks or wishes to think science is from its effects upon the extra-scientific domain rather than in terms of a patient and critical penetration of its intrinsic structure. (shrink)

Shakespeare continues to articulate the central problems of our intellectual inheritance. The plays of a Renaissance playwright still seem to be fundamental to our understanding and experience of modernity. Key philosophical questions concerning value, meaning and justice continue to resonate in Shakespeare's work. In the course of rethinking these issues, Philosophical Shakespeares focuses on and encourages the growing dissolution of boundaries between literature and philosophy. Philosophical Shakespeares includes contributions from the first rank of contemporary criticism, drawing together original and previously (...) unpublished essays by leading European and US scholars. The approach throughout is interdisciplinary and ranges from problem-centered readings of particular plays to more general elaborations on the significance of Shakespeare in relation to individual thinkers or philosophical traditions. (shrink)

The rise of literary theory spawned the rise of anti-aestheticism, so that even for cultural theorists, discussions concerning aesthetics were often carried out in a critical shorthand that failed to engage with the particularity of the work of art, much less the specificities of aesthetic experience. This book introduces the notion of a new aestheticism--"new" insofar as it identifies a turn taken by a number of important contemporary thinkers towards the idea that focussing on the specifically aesthetic impact of a (...) work of art or literature has the potential to open radically different ways of thinking about identity, politics and culture. (shrink)